The Southern African Clothing and Textile Workers Union (SACTWU) is the biggest union in the clothing, textile and leather industry, with more than 100 000 members. It negotiates wages for the vast majority of workers in the clothing, textile and leather industry in South Africa, and the agreements cover over 150 000 workers.

SACTWU is the 6th largest affiliate of the Congress of South African Trade Unions (COSATU). The union was born through the merger of ACTWUSA and GAWU in September 1989.