The Federation of Trade Unions of Ukraine (known by its Ukrainian acronym, FPU) is an all-Ukrainian voluntary association of trade unions that represents national-level industrial sector in the Crimea and the city of Kiev and it surrounding region. It is the largest trade union confederation in Ukraine, with more than 4.8 million members. As of 1 August 2019, 44 national trade unions and 27 regional trade unions were affiliated to the FPU.

The Federation of Independent Trade Unions of Ukraine was established after Ukraine became independent on 6 October 1990.